In Brugada syndrome, which medication class is generally avoided because it can exacerbate conduction abnormalities?

• A. Sodium channel blockers
• B. Beta-blockers
• C. Calcium channel blockers
• D. Potassium channel blockers

Answer: (A)

In Brugada syndrome, the heart’s conduction is already impaired due to dysfunctional sodium channels. Drugs that block sodium channels further slow depolarization and conduction, especially in the right ventricular outflow tract, which can precipitate dangerous ventricular arrhythmias. That makes sodium channel blockers the class to avoid in this condition. Examples like flecainide, propafenone, and procainamide can worsen the conduction abnormality and provoke arrhythmias, so they’re avoided in daily management. Other drug classes don’t directly reduce the sodium current in the same way, so they’re not the primary concern here, though each medication should be used with caution in Brugada patients.